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M9480827.TXT
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1994-09-05
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Document 0827
DOCN M9480827
TI Evaluation of a human immunodeficiency virus-1 antibody immunoblot for
the confirmation of oral specimens.
DT 9410
AU Griffin CK; Chun JK; Allen NM; Gaudette ND; Erbling MC; Jacobs AL;
Goldstein AS; Cimler BM; Epitope, Inc., Beaverton, Oregon.
SO Abstr Gen Meet Am Soc Microbiol. 1994;94:622 (abstract no. V-29). Unique
Identifier : AIDSLINE ASM94/94313118
AB Western blot (WB) assays are considered the gold standard for confirming
retroviral screening test results. Specimens obtained with the OraSure
oral specimen collection device have been extensively tested for the
detection of antibodies to HIV and other viral infections. An HIV-1 WB
was developed for the confirmation of the immunostatus of OraSure
specimens. To evaluate the performance of this WB, paired serum and oral
samples collected from 226 seropositive and 204 seronegative subjects
were tested. The serum specimens were tested using an FDA-licensed HIV-1
WB kit; the matching OraSure specimens were tested using the OraSure WB
assay. Among the 226 confirmed seropositive samples, the OraSure HIV-1
WB was positive for 224 samples and indeterminate for the remaining two.
No false negative samples were observed. None of the 204 specimens
identified as HIV-1 non-reactive by EIA testing was found to be positive
by either the OraSure HIV-1 WB or the licensed serum WB.
DE Acquired Immunodeficiency Syndrome/BLOOD/*DIAGNOSIS/PREVENTION &
CONTROL Antibodies, Viral/*ANALYSIS/BLOOD Comparative Study Human
*HIV Seronegativity HIV Seropositivity/BLOOD/*DIAGNOSIS
HIV-1/*IMMUNOLOGY/ISOLATION & PURIF Immunoenzyme Techniques Mass
Screening/METHODS Mouth Mucosa/IMMUNOLOGY/*MICROBIOLOGY Predictive
Value of Tests Specimen Handling/METHODS MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).